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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation, other
Remarks:
Prediction of in vivo skin sensitisation
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
OECD Toolbox Version 4.1. The toolbox is a software application to identify and fill (eco)toxicoligy data gaps for chemical hazard assesment. The toolbox is developed in cooperation with OECD and ECHA. Reference see www.qsartoolbox.org

Data source

Reference
Reference Type:
other: QSAR Toolbox prediction
Title:
Unnamed
Year:
2018
Report Date:
2018

Materials and methods

Test guideline
Guideline:
other: REACH Guidande on QSARs R6. Read-across using OECD Toolbox version 4.1.

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Details on test material:
Lot/batch No.: 201713807
Specific details on test material used for the study:
SMILES: ON=C1C(=O)NC(=O)NC1=O

Results and discussion

In vivo (LLNA)

Results
Remarks on result:
other: QSAR prediction result

Any other information on results incl. tables

The OECD Toolbox V.4.1. made read-across from 1,3-Dimethyl-4-aminouracil CAS 6642-31-5, 5,5'-(1H-isoindole-1,3(2H)-diylidene)dibarbituric acid CAS 36888-99-0, Succinimide CAS 123-56-8, tetrahydrocyclopenta[c]pyrrole-1,3(2H,3aH)-dione CAS 5763-44-0, and Caffeine CAS 58-08-2 all of which were not considered as skin senstisers and predicted 5-hydroxyiminobarbituric acid to be negative for skin sensitisation.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Test substance is not a skin sensitizer based on OECD-toolbox prediction and read-across
Executive summary:

The OECD Toolbox version 4.1. was used for prediction and read-across. Only the result in the applicability domain was accepted and the target substance 5-hydroxyiminobarbituric acid was predicted negative for skin sensitisation.