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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
OECD Toolbox Version 4.1. The toolbox is a software application to identify and fill (eco)toxicology data gaps for chemical hazard assessment. The toolbox is developed in cooperation with OECD and ECHA. For reference see www.qsartoolbox.org

Data source

Reference
Reference Type:
other: QSAR Toolbox prediction
Title:
Unnamed
Year:
2018
Report Date:
2018

Materials and methods

Test guideline
Guideline:
other: REACH Guidance on QSARs R.6.

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Details on test material:
Lot/batch No.: 201713807
Specific details on test material used for the study:
SMILES: ON=C1C(=O)NC(=O)NC1=O

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
ca. 4 570 mg/kg bw
Remarks on result:
other:
Remarks:
QSAR predicted value

Any other information on results incl. tables

The OECD Toolbox version 4.1. was used for prediction of acute toxicity (LD50) and read-across were performed from related substances. Only the result in the applicability domain is accepted. The predicted LD 50 for the target substance 5-hydroxyiminobarbituric acid was 4570 mg/kg.

Thus, the QSAR prediction does not indicate alert for acute toxicity in relation to classification.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
Test substance is not acute toxic based on OECD Toolbox prediction and read-across
Executive summary:

The OECD Toolbox version 4.1. was used for prediction of acute toxicity (LD50) and read-across were performed from related substances. Only the result in the applicability domain is accepted. The predicted LD 50 for the target substance 5-hydroxyiminobarbituric acid was 4570 mg/kg. Thus, the QSAR prediction does not indicate alert for acute toxicity in relation to classification.