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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018-06-07 to 2018-08-16
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Version / remarks:
1997
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
-1.2
Temp.:
25 °C
pH:
2
Conclusions:
Violuric acid was determined to have a logPow value of -1.2 at 25°C.
Executive summary:

The octanol-water partition coefficient of violuric acid was determined according to OECD test guideline no. 107: 'Partition Coefficient (n-octanol/water): Shake Flask Method'.

Violuric acid is an ionized substance and therefore, the test was performed at pH 2.0 where test the test substance is in undissociated form to ensure worst case scenario for parttition into the octanol phase.

Volume ratios for 1 -octanol and water phase were selected according to the OECD guidance and the 1 -octanol: water ratios were as follows: Condition 1) 1:2, condition 2) 1:1 and condition 3) 2:1. Duplicate tests were performed for each test condition. The 1 -octanol phase were prior to the test saturated with the buffer solution (10 mmol/L potassium dihydrogen phosphate) and vice versa. The test item was dissolved in the buffer solutiuon saturated with 1 -octanol and measured with HPLC. After the end of the test test substance concentration in each phase was measured by HPLC.

The range of logPow value was -1,28 to -1.14 and were within the range of +/- 0.3 units and the material balance was > 98%. The test was thgus considered reliable.

In conclusion, the logPow of VA is -1.2 at 25°C.

Description of key information

The octanol-water partition coefficient was determined according to OECD TG 107: Shake Flask Method and violuric acid was found to have a logPow value of -1.2 at 25°C.

Key value for chemical safety assessment

Log Kow (Log Pow):
-1.2
at the temperature of:
25 °C

Additional information