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Physical & Chemical properties

Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018-06-13 to 2018-08-16
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Version / remarks:
version 2009
Deviations:
no
GLP compliance:
yes
Type of method:
Laser scattering/diffraction
Key result
Percentile:
D25
Mean:
112 µm
St. dev.:
3.73
Key result
Percentile:
D50
Mean:
163 µm
St. dev.:
4.79
Key result
Percentile:
D75
Mean:
243 µm
St. dev.:
12.3
Conclusions:
The median size of the test item x50 was determined to be 163 ± 7.9 µm.
Executive summary:

A package of physicochemical testing, including a particle size distribution determination, was performed by Chemicals Evaluation and Research Institue, Kurume, Japan, to determine certain physicochemical properties of the test substance. The particle size distribution determination was performed using the laser diffraction method in accordance with ISO 13320:2009, and in accordance with GLP. The results indicated that median particle size of test item (x50) is 163 µm.

Description of key information

A package of physicochemical testing, including a particle size distribution determination, was performed by Chemicals Evaluation and Research Institue, Kurume, Japan, to determine certain physicochemical properties of the test substance. The particle size distribution determination was performed using the laser diffraction method in accordance with ISO 13320:2009, and in accordance with GLP. The results indicated that median particle size of test item (x50) is 163 µm.

Additional information