Registration Dossier
Registration Dossier
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EC number: 210-565-7 | CAS number: 618-83-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25.1.-.10.3.1993
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 5-hydroxyisophthalic acid
- EC Number:
- 210-565-7
- EC Name:
- 5-hydroxyisophthalic acid
- Cas Number:
- 618-83-7
- Molecular formula:
- C8H6O5
- IUPAC Name:
- 5-hydroxyisophthalic acid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.1 g
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 1 h , 24 h, 48 h, 72 h
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 1, 24, 48, 72 h
- Score:
- >= 0 - <= 3
- Max. score:
- 3
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 1, 24, 48, 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 1, 24, 48, 72 h
- Score:
- >= 0 - <= 2
- Max. score:
- 2
Any other information on results incl. tables
| animal | 1 h | 24 h | 48 h | 72 h | |
| 1 | cornea | 0 | 0 | 0 | 0 |
| iris | 0 | 0 | 0 | 0 | |
| conjunctivae | 1 | 0 | 1 | 1 | |
| 2 | cornea | 1 | 1 | 0 | 0 |
| iris | 0 | 0 | 0 | 0 | |
| conjunctivae | 2 | 2 | 1 | 2 | |
| 3 | cornea | 1 | 3 | 3 | 3 |
| iris | 0 | 0 | 0 | 0 | |
| conjunctivae | 2 | 2 | 1 | 1 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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