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EC number: 701-284-5 | CAS number: 2137881-70-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study need not be conducted because the available information indicates that the criteria are met for classification as corrosive to the skin or irritating to eyes
Data source
Materials and methods
Test material
- Reference substance name:
- Formic acid
- EC Number:
- 200-579-1
- EC Name:
- Formic acid
- Cas Number:
- 64-18-6
- Molecular formula:
- CH2O2
- IUPAC Name:
- formic acid
- Reference substance name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- Water
- Reference substance name:
- Propylidynetrimethanol
- EC Number:
- 201-074-9
- EC Name:
- Propylidynetrimethanol
- Cas Number:
- 77-99-6
- Molecular formula:
- C6H14O3
- IUPAC Name:
- 2-ethyl-2-(hydroxymethyl)propane-1,3-diol
- Reference substance name:
- Pentaerythritol
- EC Number:
- 204-104-9
- EC Name:
- Pentaerythritol
- Cas Number:
- 115-77-5
- Molecular formula:
- C5H12O4
- IUPAC Name:
- 2,2-Bis(hydroxymethyl)-1,3- propanediol
- Test material form:
- liquid: viscous
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Results and discussion
Any other information on results incl. tables
There are no valid studies with respect to the eye irritation of formic acid. However, according to OECD TG 405 (adopted 24thApril 2002) corrosivity to the eyes is assumed based on the following:
1. Formic acid fulfils the criteria for a caustic compound (pH<2). In this case the OECD guideline assumes corrosivity to the eyes.
2. Formic acid is classified as corrosive to the skin (causes severe burns, R35) according to EU criteria. OECD TG 405 concludes that a similar effect (corrosivity) is expected for the eyes and that no testing is needed
3. Similarly, the potential to cause severe eye lesions is assumed for
skin corrosive substances in Directive 67/548/EEC and Regulation
1272/2008/EC
Formulations or preparations containing formic acid, can be classified based on the published specific concentration limits. No caustic effect is assumed for preparations with concentrations of formic acid below 10%, which should be labelled as irritant to the eye (R 36).
The harmonised classification and labelling of formic acid according to Annex I to Directive 67/548/EEC (Regulation 1272/2008/EC, Table 3.2 p. 1067) is
Index No |
International Chemical Identification |
EC No |
CAS No |
Classification |
Labelling |
Concentration Limits |
Notes |
607-001-00-0 |
formic acid … % |
200-579-1 |
64-18-6 |
C; R35 |
C R: 35 S: (1/2-)23-26-45 |
C; R35: C≥90 % C; R34: 10 %≤C < 90 % Xi; R36/38: 2 %≤C < 10 %
|
B |
Note B :
Some substances (acids, bases, etc.) are placed on the market in aqueous solutions at various concentrations and,therefore, these solutions
require different classification and labelling since the hazards vary at differentconcentrations.
In Part 3 entries with Note B have a general designation of the following type: ‘nitric acid … %’.In this case the supplier must state the percentage
concentration of the solution on the label.Unless otherwisestated, it is assumed that the percentage concentration is calculated on a weight/weight basis.
The harmonised classification and labelling of formic acid according to Regulation 1272/2008/EC,Table 3.1 p. 528) is
Index No |
International Chemical Identification |
EC No |
CAS No |
Classification |
Labelling |
Specific Conc. Limits, M-factors |
Notes |
|||
|
|
|
|
Hazard Class and Category Code(s) |
Hazard statement Code(s) |
Pictogram, Signal Word Code(s) |
Hazard statement Code(s) |
Suppl. Hazard statement Code(s) |
|
|
607-001-00-0 |
formic acid … % |
200-579-1 |
64-18-6 |
Skin Corr. 1A |
H314 |
GHS05 Dgr |
H314 |
|
Skin Corr. 1A; H314: C≥90 % Skin Corr. 1B; H314: 10 %≤ C < 90 % Skin Irrit. 2; H315: 2 %≤ C < 10 % Eye Irrit.2; H319: 2 %≤ C < 10 % |
B |
H314: Causes severe skin burns and eye damage
H315: Causes skin irritation
H318: Causes serious eye damage
H319: Causes serious eye irritation
On this basis, since the reaction mass of 2,2-bis(formyloxymethyl)propane-1,3-diyl diformate and formic acid contains formic acid at concentrations > 10%, classification for eye irritation is not appropaite: the substance is considered to be corrosive and is classified as “causes severe burns”, Risk Phrase R34 according to Directive 67/548/EEC and as CLP Category 1B “causes severe skin burns and eye damage” (GHSS05 Dgr; H314) according to the Regulation 1272/2008/EC. Further testing is not required.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Remarks:
- Criteria used for interpretation of results: other: CLP Directive: EC 1272/2008 ( EU GHS)
- Executive summary:
The reaction mass of 2,2-bis(formyloxymethyl)propane-1,3-diyl diformate and formic acid contains formic acid at concentrations up to 59% w/w which exceeds the 10% limit considered for causticity. On this basis, the substance is considered to be caustic and expected to cause more severe eye damage than irritation. The substances meets the criteria for classification as “causes severe burns”, Risk Phrase R34 according to Directive 67/548/EEC and as CLP Category 1B “causes severe skin burns and eye damage” (GHSS05 Dgr; H314) according to the Regulation 1272/2008/EC. Further testing in respect of eye irritation is not required.
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