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EC number: 701-284-5 | CAS number: 2137881-70-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- It is considered appropriate to address the data requirements for reaction mass of 2,2-bis(formyloxymethyl)propane-1,3-diyl diformate and formic acid by read-across to the available studies on structurally similar substances.
Reaction mass of 2,2-bis(formyloxymethyl)propane-1,3-diyl diformate and formic acid is comprised of formic acid (free) up to 59%, propylidynetrimethanol (trimethylolpropane, TMP) up to 35%, and pentaerythritol up to 19.6%.
Aquatic microorganism toxicity studies are available on formic acid, propylidynetrimethanol (trimethylolpropane, TMP), and pentaerythritol. The data requirements for reaction mass of 2,2-bis(formyloxymethyl)propane-1,3-diyl diformate and formic acid are addressed by read-across to formic acid, propylidynetrimethanol (TMP) and pentaerythritol. - Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Specific details on test material used for the study:
- Formic acid, propylidynetrimethanol (trimethylolpropane, TMP), and pentaerythritol are being used as a read across for 2,2-bis(formyloxymethyl)propane-1,3-diyl diformate and formic acid.
- Key result
- Duration:
- 13 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 72 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks on result:
- other: Key data from formic acid study
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks on result:
- other: Key data from TMP study
- Duration:
- 3 h
- Dose descriptor:
- EC10
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks on result:
- other: Key data from TMP study
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks on result:
- other: Key data from pentaerythritol study
- Duration:
- 3 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks on result:
- other: Key data from pentaerythritol study
- Details on results:
- The key data from aquatic microorganism toxicity studies on formic acid, propylidynetrimethanol (trimethylolpropane, TMP), and pentaerythritol are used for weight of evidence read across to reaction mass of 2,2-bis(formyloxymethyl)propane-1,3-diyl diformate and formic acid.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The toxicity of the target substance, reaction mass of 2,2-bis(formyloxymethyl)propane-1,3-diyl diformate and formic acid, to aquatic microorganisms was estimated to be 13 d NOEC = 72 mg/L and 3 h EC50 = >1000 mg/L, based on worst case read-across studies on activated sludge (from domestic and predominately domestic sewage, respectively).
- Executive summary:
Studies on microorganism toxicity are available for the read-across substances formic acid, propylidynetrimethanol (trimethylolpropane, TMP) and pentaerythritol:
The inhibition control of a ready biodegradability study of formic acid was used for the assessment of toxicity to microorganisms. No inhibition of degradation activity was shown at a test substance concentration of 72 mg/L, and was therefore considered to be the NOEC.
The respiration inhibition of activated sludge from predominantly domestic sewage treatment plant by TMP was determined according to the EU Guideline C.11 with an incubation time of 3 hours. The EC50 and the EC10 for TMP were determined to be > 1000 mg/L.
The toxicity of pentaerythritol to activated sewage sludge was investigated in a respiration inhibition test according to OECD test guideline 209. Following 3 hours exposure to pentaerythritol the EC50 was observed to be > 1000 mg/L (based on nominal exposure concentrations), the corresponding NOEC was observed to 1000 mg/L.
Reference
Description of key information
The lowest available EC50 for the read-across substances was found to be 1000 mg/l.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 1 000 mg/L
- EC10 or NOEC for microorganisms:
- 72 mg/L
Additional information
Studies on microorganism toxicity are available for the read-across substances formic acid, propylidynetrimethanol (trimethylolpropane, TMP) and pentaerythritol:
For formic acid the inhibition control of a test on ready biodegradability was used for the assessment of toxicity to microorganisms. As at a test substance concentration of 72 mg/L no inhibition of degradation activity occured, so this is considered to be the NOEC.
The respiration inhibition of activated sludge from predominantly domestic sewage treatment plant by TMP was determined according to the EU Guideline C.11 with an incubation time of 3 hours. The concentrations tested were 10, 100 and 1000 mg/L. EC50 of the reference substance 3,5 - dichlorophenole was 9.2 mg/L ( 95% C.I. 3 - 24 mg/L). The respiration rates of the 2 controls differed less than 15% from each other.
The EC50 and the EC10 for TMP were determined to be > 1000 mg/L.
The toxicity of pentaerythritol to activated sewage sludge was investigated in a respiration inhibition test according to OECD test guideline 209. Following three hours exposure to pentaerythritol the EC50 was observed to be > 1000 mg/L (based on nominal exposure concentrations), the corresponding NOEC was observed to 1000 mg/L.
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