Protein hydrolyzates, silk, reaction products with 3-chloro-2-hydroxypropyl-cocoalkyl-dimethylammonium chloride

Boiling point

Administrative data

Endpoint:

boiling point

Data waiving:

study technically not feasible

Justification for data waiving:

the study does not need to be conducted because chemical change occurred during the melting point study

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From October 27, 2017 to February 27, 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Deviations:

not specified

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Deviations:

not specified

GLP compliance:

yes

Type of method:

capillary method

Key result

Decomposition:

yes

Decomp. temp.:

ca. 89.7 °C

Remarks on result:

not determinable

Results:

Suspected decomposition was observed from 89.7°C with the release of colourless gas and the test sample moving up the tube. At 160°C the sample was observed to pop out of the tube with more sample ejected at 184°C. As a result further testing was stopped.

Conclusions:

Under the study conditions, melting point of the test substance could not be determined due to decomposition at 89.7°C.

Executive summary:

A study was conducted to determine the melting point of the test substance, using the capillary method (with photocell detection), according to OECD Guideline 102 and EU Method A.1, in compliance with GLP. During the study, suspected decomposition was observed from 89.7°C with the release of colourless gas and the test sample moving up the tube. At 160°C the sample was observed to pop out of the tube with more sample ejected at 184°C. As a result further testing was stopped. Under the study conditions, melting point of the test substance could not be determined due to decomposition at 89.7°C (Chilworth, 2018).