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EC number: 701-354-5 | CAS number: -
OD 570 nmWell 1
OD 570 nmWell 2
Mean OD of 2 Wells
of 2 Wells blank
of 3 tissues
Rel. Viability [%] Tissue1, 2 + 3*
of viability values
Mean Rel. Viability
* Relative viability [rounded values]: [100 x (absorbance test item/ postive control/ negative control)]/ mean absorbance negative control
** Mean relative viability [rounded values]: [100 x (mean absorbance test item/ postive control/ negative control)]/ mean absorbance negative control
This in vitro study was performed to assess the irritation potential of Sodium cocopropylenediamine propionate, CAS 97659-50-2 by means of the Human Skin Model Test according to OECD TG 439.
The test item did not reduce MTT (pre-test for direct MTT reduction), and it did not dye water, when mixed with it (pre-test for colour interference). Also its intrinsic colour was not intensive. Consequently, additional tests with freeze-killed or viable tissues were not necessary.
Three tissues of the human skin model EpiSkin™ were treated with the test item, the negative control (PBS) or the positive control (5% sodium lauryl sulfate) for 15 minutes.
After treatment with the negative control the absorbance values were well within the required acceptability criterion of mean OD 0.6 till ≤ 1.5 thus showing the quality of the tissues.
Treatment with the positive control induced a sufficient decrease in the relative absorbance as compared to the negative control thus ensuring the validity of the test system.
After treatment with the test item the mean relative absorbance value was 100.6%. This value is above the threshold for irritancy of ≤ 50%. Therefore, the test item is not considered to possess an irritant potential.
In conclusion, it can be stated that in this study and under the experimental conditions reported, Sodium cocopropylenediamine propionate, CAS 97659-50-2 is not irritant to skin according to UN GHS and EU CLP regulation.
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