Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Boric acid was tested in a Buehler method skin sensitisation test (Wnorowski, 1994 ) applied at a concentration of 95 % (powder moistened with water) during both the induction and challenge phase of the test. No signs of skin sensitisation were observed.No evidence of skin sensitisation in humans exposed occupationally to borates has been reported (Bruze et al., 1995).

In two Magnussen Kligman guinea pig studies, methanol did not show any relevant skin sensitisation potential (BASF AG 1979a and b).

Based on the evidence on both hydrolysis products, boric acid and methanol, TMB is judged to have no relevant potential for skin sensitisation.


Migrated from Short description of key information:
Based on the evidence on both hydrolysis products, boric acid and methanol, TMB is judged to have no relevant potential for skin sensitisation.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

There are no data to suggest that boric acid is a respiratory sensitiser.


Migrated from Short description of key information:
There are no data to suggest that boric acid is a respiratory sensitiser.

Justification for classification or non-classification

No classification is required for trimethyl borate as the hydrolysis product boric acid did not show any potential for skin or respiratory sensitisation.