Registration Dossier

Toxicological information

Acute Toxicity: other routes

Currently viewing:

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
No data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards with acceptable restrictions.

Data source

Reference
Reference Type:
publication
Title:
Boric acid ointment: A study of possible intoxication in the treatment of burns.
Author:
Pfeiffer CC, Hallman LF & Gersh I.
Year:
1945
Bibliographic source:
J. Amer. Med. Assoc. 128 (4) 266 - 274.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: No data
Deviations:
not specified
Principles of method if other than guideline:
No data
GLP compliance:
no
Remarks:
Study pre-dates GLP
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: Boric acid
- Molecular formula: H3BO3
- Molecular weight: 61.8
- Smiles notation:B(OH)3
- Substance type: Inorganic
- Physical state: Solid
- Analytical purity: > 99.9 % w/w
- Stability under test conditions: Stable
- Other: White and odourless.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intravenous
Vehicle:
not specified
Doses:
No data
No. of animals per sex per dose:
40 animals
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 330 mg/kg bw
Based on:
test mat.
Clinical signs:
The pre-lethal symptom in these animals was depression.

Applicant's summary and conclusion

Conclusions:
The LD50 in rats was 1330 mg/kg bw. The pre-lethal symptom in these animals was depression.