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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
other: SCCS/1511/13
Adequacy of study:
key study
Study period:
na
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation

Data source

Reference
Title:
Scientific Committee on Consumer Safety Opinion on Lawsonia Inermis (Henna) Colipa no C169
Author:
SCCS
Year:
2013
Bibliographic source:
ISBN 978-92-79-30118-6
Report date:
2013

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Version / remarks:
1981
Deviations:
not specified
GLP compliance:
not specified
Test type:
other: not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Lawsonia inermis, ext.
EC Number:
284-854-1
EC Name:
Lawsonia inermis, ext.
Cas Number:
84988-66-9
Molecular formula:
na
IUPAC Name:
Lawsonia inermis, ext.
Test material form:
solid: particulate/powder

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
not specified
No. of animals per sex per dose:
Not specified
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
>= 2 000 mg/kg bw
Based on:
not specified
Mortality:
Not specified
Clinical signs:
other: Not specified

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The calculated oral median lethal dose was > 2000 mg/kg bw.