Registration Dossier
Registration Dossier
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EC number: 641-132-4 | CAS number: 93240-93-8
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful for fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 131.2 mg/L
Additional information
No experimental data are available for of 2-[2-(dimethylamino)ethoxy]-N-methylethanamine (TMAEE, CAS 93240-93-8). Therefore, the assessment of toxicity of the substance to fish was based on the available experimental read-across data for a structurally similar substance BDMAEE (CAS 3033-62-3):
In a GLP study, conducted according to OECD 203, Danio rerio were exposed to the substance for a period of 96 hours. The test was performed under semi-static freshwater conditions. As the substance causes a light pH-shift to more alkaline conditions with increasing test substance concentrations, the highest test solution (1000 mg/L) was also tested after pH-adjustment. However, the pH-adjustment in the additional 1000 mg/L group did not decrease the mortality rate over 96 h. In this study, the 96‑h LC50 was found to be 131 mg/L, based on unbuffered test solutions (nominal, [56]). Analytical monitoring demonstrated that the substance was stable over the exposure period.
Based on the available experimental read-across data, TMAEE (CAS 93240-93-8) is concluded to be with high probability acutely not harmful for fish.
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