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EC number: 641-132-4 | CAS number: 93240-93-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.07 mg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.704 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.007 mg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 34 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 0.451 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.045 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.049 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
Conclusion on classification
Classification Justification for TMAEE (CAS 93240-93-8) ‘mono-constituent’:
‘Mono-constituent’ - Official classification regarding environmental hazards
Aquatic compartment
According to Regulation (EC) 1272/2008 Annex VI Table 3.1, the substance is not classified as hazardous to the environment.
According to Regulation (EC) 1272/2008 Annex VI Table 3.2, the substance is not classified as hazardous to the environment.
‘Mono-constituent’: Self-classification
Aquatic compartment
The classification of the TMAEE (CAS 93240 -93 -8) was based on experimental data from the substance itself and from read-across data from the structurally similar substance BDMAEE (CAS 3033-62-3):
Following GHS/CLP, the substance is not to be classified as acutely hazardous to the aquatic environment, based on the available acute data. Based on the available acute and chronic data, the substance is not to be classified as chronically hazardous to the aquatic environment.
Rationale:
According to the criteria outlined in Table 4.1.0(a) (Commission Regulation (EU) No 286/2011 amending Regulation (EC) No 1272/2008) the substance is not to be classified as acutely hazardous to the aquatic environment as the lowest acute effect value is higher than 1 mg/L (algae: 72-h ErC50: 70.4 mg/L; BASF SE, 2019, report no.: 60E0034/19X015).
Chronic toxicity data are available only for algae. Therefore, classification is based on the available chronic data for algae and acute toxicity data for the trophic levels not covered by chronic data (fish and aquatic invertebrates).
- Classification based on chronic toxicity data (algae): The substance is not rapidly degradable (see IUCLID chapter 5.2.1) and the ErC10 is > 1 mg/L (algae: 72-h ErC10 = 41 mg/L, BASF SE, 2019, report no.: 60E0034/19X015). According to the criteria outlined in Table 4.1.0(b) (i) (Commission Regulation (EU) No 286/2011 amending Regulation (EC) No 1272/2008), the substance is not to be classified as chronically hazardous to the aquatic environment.
- Classification based on acute toxicity data (fish and Daphnids): The lowest EC50 was determined for aquatic invertebrates (Read-across to BDMAEE, CAS 3033-62-3:48-h EC50 = 102 mg/L; RCC Ltd., 2008), the substance is not rapidly degradable (see IUCLID chapter 5.2.1), the log Kow is < 4, and the estimated BCF values are < 500 L/kg. According to the criteria outlined in Table 4.1.0(b) (iii) (Commission Regulation (EU) No 286/2011 amending Regulation (EC) No 1272/2008), the substance is not to be classified as chronically hazardous to the aquatic environment.
In summary,based on the available acute and chronic data from TMAEE itself and from read-across data for BDMAEE (CAS 3033-62-3), the mono-constituent TMAEE (CAS 93240-93-8) is neither to be classified as acutely hazardous nor to be classified as chronically hazardous to the aquatic environment.
Atmospheric compartment
The substance is not in Annex I of Regulation (EC) 2037/2000 on substances that deplete the ozone layer.
The substance does not belong to the greenhouse gases listed in P Forster, PV Ramaswamy et al. Changes in Atmospheric Constituents and in Radiative Forcing. In: Climate Change 2007: The Physical Basis. Contribution of Working Group I to the Fourth Assessment Report of the Intergovernmental Panel on Climate Change.
Classification Justification for relevant impurities of TMAEE (CAS 93240-93-8):
TMAEE (CAS 93240-93-8)is a mono-constituent substance that has a purity of 80-100 % (w/w). According to the ‘Guidance on the Application of the CLP-Criteria” (v4.1; ECHA, 2015) the relevant impurities of a substance still meeting the definition ‘mono-constituent’ may influence the classification of the substance. Therefore, the following impurities of TMAEE (CAS 93240‑93-8) identified as relevant constituents were additionally considered in terms of classification purposes:
- 2-[2-(dimethylamino)ethoxy]-N,N-dimethylethanamine (BDMAEE;CAS 3033 -62 -3); 1 – 9.99 %:
no harmonized CLP classification according to Regulation No (EC) 1272/2008 Annex VI; CLP self-classification: not classified
- 2-[2-(dimethylamino)ethoxy]ethanamine (ADAN, CAS 85322-63-0); 1 – 9.99 %:
no harmonized CLP classification according to Regulation No (EC) 1272/2008 Annex VI; CLP self-classification: not classified
- N-methyl-2-[2-(methylamino)ethoxy]ethanamine (ODAN, CAS 2620-27-1); 4 %:
no harmonized CLP classification according to Regulation No (EC) 1272/2008 Annex VI; CLP self-classification: not classified
- 2-[2-(dimethylamino)ethoxy]ethanol (DMAEE, CAS 1704-62-7);0 – 0.75 %:
no harmonized CLP classification according to Regulation No (EC) 1272/2008 Annex VI; CLP self-classification: not classified
- N-Methylmorpholine (NMM, CAS 109-02-4); 0.1 – 0.5 %:
no harmonized CLP classification according to Regulation No (EC) 1272/2008 Annex VI; CLP self-classification: not classified
The data matrix used for classification purposes of the relevant constituents of TMAEE (CAS 93240-93-8) are given in ‘Read-Across Justification Document’-attachment (see e.g. IUCLID chapters 6.1.1, 6.1.3 etc.).
‘Relevant Constituents of TMAEE (CAS 93240-93-8)’ - Official classification regarding environmental hazards
Aquatic compartment
According to Regulation (EC) 1272/2008 Annex VI Table 3.1, none of the relevant constituents are classified as hazardous to the environment.
According to Regulation (EC) 1272/2008 Annex VI Table 3.2, none of the relevant constituents are classified as hazardous to the environment.
‘Relevant Constituents of TMAEE (CAS 93240-93-8)’ - Self-classification
Following GHS/CLP, none of the relevant constituents of TMAEE (CAS 93240-93-8) is to be classified as acutely hazardous to the aquatic environment. Furthermore, none of the relevant components is to be classified as chronically hazardous to the aquatic environment.
Rationales:
BDMAEE (CAS 3033-62-3):
Regarding acute toxicity,algae turned out to be the most sensitive trophic level with a 72-h ErC50 of 24 mg/L (RCC Ltd., 2008). According to the criteria outlined in Table 4.1.0(a) (Commission Regulation (EU) No 286/2011 amending Regulation (EC) No 1272/2008) the substance is not to be classified as acutely hazardous to the aquatic environment as the lowest acute effect value is higher than 1 mg/L.
Chronic toxicity data are available only for algae. Therefore, classification is based on the available chronic data for algae and acute toxicity data for the trophic levels not covered by chronic data (fish and aquatic invertebrates).
Classification based on chronic toxicity data (algae): The substance is not rapidly degradable and the ErC10 is > 1 mg/L (algae: 72 -h ErC10 = 5 mg/L). According to the criteria outlined in Table 4.1.0(b) (i) (Commission Regulation (EU) No 286/2011 amending Regulation (EC) No 1272/2008), the substance is not to be classified as chronically hazardous to the aquatic environment.
Classification based on acute toxicity data (fish and Daphnids): The lowest EC50 was determined for aquatic invertebrates (48-h EC50 = 102 mg/L), the substance is not rapidly degradable, the log Kow is < 4. According to the criteria outlined in Table 4.1.0(b) (iii) (Commission Regulation (EU) No 286/2011 amending Regulation (EC) No 1272/2008), the substance is not to be classified as chronically hazardous to the aquatic environment.
In summary, based on the available acute and chronic toxicity data BDMAEE (CAS 3033-62-3) is neither to be classified as acutely hazardous, nor to be classified as chronically hazardous to the aquatic environment.
ADAN (CAS 85322-63-0):
No experimental data are available for this relevant constituent. The assessment is, therefore, based on calculated (Q)SAR data.
Regarding acute toxicity,the lowest estimated EC/LC50 value available is a LC50 of >100 mg/L for fish (SarPy/IRFMN v1.0.2; [86]); the substance was within the model’s applicability domain. According to the criteria outlined in Table 4.1.0(a) (Commission Regulation (EU) No 286/2011 amending Regulation (EC) No 1272/2008) the substance is not to be classified as acutely hazardous to the aquatic environment as the lowest acute effect value is higher than 1 mg/L.
Chronic toxicity data are not available. Therefore, classification is based on the available acute toxicity data for the trophic levels not covered by chronic data (fish, aquatic invertebrates and algae). The lowest estimated EC/LC50 value available is a LC50 of >100 mg/L for fish (SarPy/IRFMN v1.0.2; [86]); the substance was within the model’s applicability domain. The substance is estimated to be not rapidly degradable, the log Kow is estimated to be < 4; the BCF is estimated to be < 500 L/kg. According to the criteria outlined in Table 4.1.0(b) (iii) (Commission Regulation (EU) No 286/2011 amending Regulation (EC) No 1272/2008), the substance is not to be classified as chronically hazardous to the aquatic environment.
In summary,ADAN (CAS 85322-63-0)is neither to be classified as acutely hazardous, nor to be classified as chronically hazardous to the aquatic environment.
ODAN (CAS 2620-27-1):
No experimental data are available for this relevant constituent. The assessment is, therefore, based on calculated (Q)SAR data.
Regarding acute toxicity,the lowest estimated EC/LC50 value available is a LC50 of >100 mg/L for fish (SarPy/IRFMN v1.0.2; [83]); the substance was within the model’s applicability domain. According to the criteria outlined in Table 4.1.0(a) (Commission Regulation (EU) No 286/2011 amending Regulation (EC) No 1272/2008) the substance is not to be classified as acutely hazardous to the aquatic environment as the lowest acute effect value is higher than 1 mg/L.
Chronic toxicity data are not available. Therefore, classification is based on the available acute toxicity data for the trophic levels not covered by chronic data (fish, aquatic invertebrates and algae). The lowest estimated EC/LC50 value available is a LC50 of >100 mg/L for fish (SarPy/IRFMN v1.0.2; [83]); the substance was within the model’s applicability domain. The substance is estimated to be rapidly degradable, the log Kow is estimated to be < 4; the BCF is estimated to be < 500 L/kg. According to the criteria outlined in Table 4.1.0(b) (iii) (Commission Regulation (EU) No 286/2011 amending Regulation (EC) No 1272/2008), the substance is not to be classified as chronically hazardous to the aquatic environment.
In summary,ODAN (CAS 2620-27-1)is neither to be classified as acutely hazardous, nor to be classified as chronically hazardous to the aquatic environment.
DMAEE (CAS 1704-62-7):
Regarding acute toxicity, aquaticinvertebrates turned out to be the most sensitive trophic level with a 48-h EC50 of >100 mg/L. According to the criteria outlined in Table 4.1.0(a) (Commission Regulation (EU) No 286/2011 amending Regulation (EC) No 1272/2008) the substance is not to be classified as acutely hazardous to the aquatic environment as the lowest acute effect value is higher than 1 mg/L.
Chronic toxicity data are available only for algae. Therefore, classification is based on the available chronic data for algae and acute toxicity data for the trophic levels not covered by chronic data.
Classification based on chronic toxicity data (algae): The substance is not rapidly degradable and the ErC10 is > 1 mg/L (algae: 72 -h ErC10 = 63 mg/L). According to the criteria outlined in Table 4.1.0(b) (i) (Commission Regulation (EU) No 286/2011 amending Regulation (EC) No 1272/2008), the substance is not to be classified as chronically hazardous to the aquatic environment.
Classification based on acute toxicity data: The lowest EC50 was determined for aquatic invertebrates (48-h EC50 >100 mg/L), the substance is not rapidly degradable, the log Kow is < 4. According to the criteria outlined in Table 4.1.0(b) (iii) (Commission Regulation (EU) No 286/2011 amending Regulation (EC) No 1272/2008), the substance is not to be classified as chronically hazardous to the aquatic environment.
In summary,based on the available acute and chronic toxicity data DMAEE (CAS 1704-62-7) is neither to be classified as acutely hazardous, nor to be classified as chronically hazardous to the aquatic environment.
NMM (CAS 109-02-4):
Regarding acute toxicity, aquaticinvertebrates turned out to be the most sensitive trophic level with a 48-h EC50 of >100 mg/L. According to the criteria outlined in Table 4.1.0(a) (Commission Regulation (EU) No 286/2011 amending Regulation (EC) No 1272/2008) the substance is not to be classified as acutely hazardous to the aquatic environment as the lowest acute effect value is higher than 1 mg/L.
Chronic toxicity data are available only for algae (read-across data from CAS 100-74-3). Therefore, classification is based on the available chronic data for algae and acute toxicity data for the trophic levels not covered by chronic data (fish and aquatic invertebrates).
Classification based on chronic toxicity data (algae): The substance is rapidly degradable and the ErC10 is > 1 mg/L (algae: 96-h ErC10 = 35.3 mg/L). According to the criteria outlined in Table 4.1.0(b) (ii) (Commission Regulation (EU) No 286/2011 amending Regulation (EC) No 1272/2008), the substance is not to be classified as chronically hazardous to the aquatic environment.
Classification based on acute toxicity data (fish and Daphnids): The lowest EC50 was determined for aquatic invertebrates (48-h EC50 of >100 mg/L), the substance is rapidly degradable, the log Kow is < 4. According to the criteria outlined in Table 4.1.0(b) (iii) (Commission Regulation (EU) No 286/2011 amending Regulation (EC) No 1272/2008), the substance is not to be classified as chronically hazardous to the aquatic environment.
In summary,based on the available acute and chronic toxicity data NMM (CAS 109-02-4) is neither to be classified as acutely hazardous, nor to be classified as chronically hazardous to the aquatic environment.
OVERALL CONCLUSION:
Summing up, all relevant constituents of the target substance TMAEE (CAS 93240-93-8) are not to be classified as acutely or chronically hazardous to the aquatic environment
Atmospheric compartment
None of the relevant constituents of TMAEE (CAS 93240-93-8) is listed in Annex I of Regulation (EC) 2037/2000 on substances that deplete the ozone layer.
None of the relevant constituents does belong to the greenhouse gases listed in P Forster, PV Ramaswamy et al. Changes in Atmospheric Constituents and in Radiative Forcing. In: Climate Change 2007: The Physical Basis. Contribution of Working Group I to the Fourth Assessment Report of the Intergovernmental Panel on Climate Change.
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