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Environmental fate & pathways

Biodegradation in water: screening tests

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Description of key information

The substance is not readily biodegradable (according to OECD critieria).

Key value for chemical safety assessment

Biodegradation in water:
under test conditions no biodegradation observed

Additional information

As no experimental data are available on the biodegradation potential of 2-[2-(dimethylamino)ethoxy]-N-methylethanamine (TMAEE; CAS 93240-93-8) read-across data from the structurally similar substance BDMAEE (CAS 3033-62-3) were used for the assessment of the biodegradation potential:

- In a study conducted equivalent to OECD Guideline 301F (Ready Biodegradability: Manometric Respirometry Test), degradation of the substance was reported to be 2% after 28 days based on oxygen consumption (Huntsman, 1996, study no.: 1928). Industrial activated sludge was used as inoculum. The criteria for ready biodegradability were not reached for BDMAEE (CAS 3033 -62 -3).

- Moreover, based on results from an inherent biodegradability test (OECD 302B) using activated sludge from an industrial source, BDMAEE is considered to be not inherently biodegradable (<10% DOC removal after 28 days, BASF AG, 1987, study no.: 3995/87.01.79).

The experimental result for the structurally similar substance BDMAEE (CAS 3033 -62 -3) is supported by the outcome of several QSAR models (BASF SE, 2018) applied to the target substance itself:

- CATALOGIC v5.12.1 MITI OECD 301 C v10.14: 59% after 28 d, based on O2 consumption, in the AD of the model

- CATALOGIC v5.12.1 BOD Kinetic OECD 301F v13.16: 17% after 28 d, based on O2 consumption, not in the AD of the model

- CATALOGIC v5.12.1 CO2 Kinetic OECD 301B v02.09: 8.7% after 28 d, based on CO2 evolution, not in th AD of the model

- BIOWIN v4.10 prediction: Not readily biodegradable, in the AD of the model

Based on the available experimental read-across data for the structurally similar substance BDMAEE (CAS 3033 -62 -3) and calculated data for the target substance itself, it can be concluded, that TMAEE (CAS 93240-93-8) is not readily biodegradable according to OECD criteria.

[Type of water: freshwater]