Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report Date:
2017

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid: viscous
Specific details on test material used for the study:
Batch number: 78-242-15

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
5.1
Temp.:
22 °C
Remarks on result:
other: pH not specified
Details on results:
The reference substance solutions and the test item solution were injected in duplicate.
Because the retention time of the test item under examination is in the range of the reference substances retention time, the Pow value could be calculated by the linear regression analysis performed using the least squares method.

Any other information on results incl. tables

Linear calibration curve parameters

Parameter m

(slope)

Parameter q

(intercept)

Parameter R2

(correlation)

4.697

5.057

0.87521

Test item

tr Mean(min)

k’

log k’

13.2

1.021

0.0089

logPow

5.10

Pow

125579

Applicant's summary and conclusion

Conclusions:
The LogPow of the test item is 5.10