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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

Bisphenol F Diglycidylether induced gene-mutation in the Ames/Salmonella mutation test and chromosomal aberrations in human lymphocytes in multiple independent testing guideline GLP studies. Furthermore, the structural analog, Bisphenol A Diglycidylether (BPADGE) induce a significant increase of the mutant frequency in L5178Y mouse lymphoma cells in culture supporting the other findings. Therefore, BPFDGE is genotoxic in vitro.

However, when Bisphenol F Diglycidylether was evaluated for genotoxicity potential in multiple GLP in vivo assays including the mouse micronucleus, rat in vivo/in vitro UDS and MutaMouse tests no evidence of genotoxicity was observed. The results of other in vivo tests for genotoxicity also supported these negative findings for BPFDGE. Therefore, Bisphenol F Diglycidylether is not genotoxic in vivo.   

Short description of key information:
Bisphenol F Diglycidylether (BPFDGE) was evaluated for the potential to induce evidence of genotoxicity in multiple in vitro and in vivo assays. These assays included tests for gene-mutation and chromosome aberrations in vitro and gene-mutation, chromosome damage repairable DNA damage in vivo.

Endpoint Conclusion: Adverse effect observed (positive)

Justification for classification or non-classification

Because Bisphenol F Diglycidylether is not genotoxic in vivo, Classification and Labeling as a Mutagen is not required.