Reaction mass of 2,2'-[methylenebis(2,1-phenyleneoxymethylene)]bis(oxirane) and 2,2'-[methylenebis(4,1-phenyleneoxymethylene)]bis(oxirane) and 2-({2-[4-(oxiran-2-ylmethoxy)benzyl]phenoxy}methyl)oxirane

Adsorption / desorption

Administrative data

Endpoint:

adsorption / desorption: screening

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: The study was conducted according to O.E.C.D. Testing Guideline No. 121 with GLP compliance.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2010

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))

Deviations:

not specified

GLP compliance:

yes

Type of method:

HPLC estimation method

Media:

soil/sewage sludge

Test material

Test material information

Constituent 1

Reference substance name:

Reaction mass of 2,2'-[methylenebis(4,1-phenyleneoxymethylene)]dioxirane and [2-({2-[4-(oxiran-2-ylmethoxy)benzyl]phenoxy}methyl)oxirane and [2,2'-[methylenebis(2,1-phenyleneoxymethylene)]dioxirane

EC Number:

701-263-0

Cas Number:

9003-36-5

Molecular formula:

C6 H6. C3 H5 Cl . C H2 O)x

IUPAC Name:

Reaction mass of 2,2'-[methylenebis(4,1-phenyleneoxymethylene)]dioxirane and [2-({2-[4-(oxiran-2-ylmethoxy)benzyl]phenoxy}methyl)oxirane and [2,2'-[methylenebis(2,1-phenyleneoxymethylene)]dioxirane

Constituent 2

Reference substance name:

Formaldehyde, polymer with 2-(chloromethyl)oxirane and phenol

IUPAC Name:

Formaldehyde, polymer with 2-(chloromethyl)oxirane and phenol

Constituent 3

Reference substance name:

Bisphenol F Diglycidylether (BPFDGE)

IUPAC Name:

Bisphenol F Diglycidylether (BPFDGE)

Details on test material:

As per IUCLID5 Sections 1.1. - 1.4.

Radiolabelling:

no

Study design

Test temperature:

Constant control HPLC column.

HPLC method

Details on study design: HPLC method:

The adsorption coefficient (Koc) was initially estimated using the Log Kow of BPFDGE in order to establish the operational parameters for the HPLC system. The reverse-phase column was cyanopropyl chemically bound resins on a silica base. The mobile phase was methanol/water (55%/45% v/v). Other operational parameters were: detection wavelength, mobile phase flow rate, and injection volume. The calibration curve was based on the retention time of six different reference compounds with published Koc values. The Dead Time (to) was based on the retention time of an unretained standard. The calibration curve was calculated as the linear regression line by plotting the logarithm of the capacity factor of the reference substances as a function of their respective Koc values. The capacity factor, k, is a function of the retention time and the dead time. The adsorption coefficient of BPFDGE was estimated by interpolation of the calculated capacity factor, k, for BPFDGE on the calibration curve.

Results and discussion

Adsorption coefficient

Adsorption coefficient 1

Type:

Koc

Value:

ca. 4 460

Adsorption coefficient 2

Type:

log Koc

Value:

ca. 3.65

Results: HPLC method

Details on results (HPLC method):

Interpolation of the calculated capacity factor for BPFDGE on the reference substance calibration curve resulted in a Log Koc of approximately 3.65.

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

The HPLC estimated Log Koc for Bisphenol F Diglycidylether was 3.65. This suggests minimal potential to adsorb to sewage sludge and soil.

Executive summary:

Bisphenol F Diglycidylether was assessed for potential to bind to sewage sludge and soil by an O.E.C.D. Testing Guideline 121 study with GLP compliance. The HPLC estimated Log Koc for Bisphenol F Diglycidylether was 3.65 under the conditions of the study. This suggests minimal potential to adsorb to sewage sludge and soil.