Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
17 October 2016 to 12 November 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
2-ethylhexyl 12-hydroxyoctadecanoate
EC Number:
249-793-7
EC Name:
2-ethylhexyl 12-hydroxyoctadecanoate
Cas Number:
29710-25-6
Molecular formula:
C26H52O3
IUPAC Name:
2-ethylhexyl 12-hydroxyoctadecanoate

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Key result
Remarks on result:
other: The partition coefficient of the test item has been determined to be 3.63 x 10^9 to >1.0 x 10^10, log10 Pow 9.56 to >10.0.
Details on results:
Preliminary Estimate: The estimated log10 Pow for the representative structure of the test item was calculated to be from 10.06

Definitive Test: The partition coefficient of the test item has been determined to be 3.63 x 10^9 to >1.0 x 10^10. Overall log10 Pow was 9.56 to >10.0.

Applicant's summary and conclusion

Conclusions:
The Partition Coefficient (n-octanol/water) was 3.63 X 10^9 to >1.0 X 10^10, log10 Pow 9.56 to >10.0.
Executive summary:

The Partition Coefficient (n-octanol/water) was 3.63 X 10^9 to >1.0 x 10^10, log10 Pow 9.56 to >10.0, using the HPLC method, designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.