Registration Dossier
Registration Dossier
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EC number: 609-105-1 | CAS number: 35249-62-8
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Version / remarks:
- OECD Guideline for the Testing of Chemicals No. 429 "Skin Sensitization: Local Lymph Node Assay" (adopted 22 July 2010)
• Method B42 Skin Sensitization (Local Lymph Node Assay) of Commission Regulation (EC) No. 440/2008 - Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile
- EC Number:
- 609-105-1
- Cas Number:
- 35249-62-8
- Molecular formula:
- C11H12BrNO2
- IUPAC Name:
- 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile
- Test material form:
- solid
Constituent 1
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Key result
- Parameter:
- SI
- Value:
- ca. 0.69
- Test group / Remarks:
- Concentration (% w/w) in acetone/olive oil 4:1
10
- Key result
- Parameter:
- SI
- Value:
- ca. 2.06
- Test group / Remarks:
- Concentration (% w/w) in acetone/olive oil 4:1
25
- Key result
- Parameter:
- SI
- Value:
- ca. 1.11
- Test group / Remarks:
- Concentration (% w/w) in acetone/olive oil 4:1
50
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item was considered to be a non-sensitizer under the conditions of the test.
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