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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study report contains limited information, pre-GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Neodecanoic acid
EC Number:
248-093-9
EC Name:
Neodecanoic acid
Cas Number:
26896-20-8
Molecular formula:
C10H20O2
IUPAC Name:
2-ethyl-2,5-dimethylhexanoic acid
Details on test material:
- Name of test material (as cited in study report): Versatic 10
- Substance type: liquid
- Analytical purity: assumed 100%

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
1, 1.5, 2, 3, or 4 ml/kg
No. of animals per sex per dose:
4 per sex per dose
Control animals:
no
Details on study design:
- Duration of observation period following administration: 10 days post dosing
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights
Statistics:
LD50 value and 95% confidence intervals were calculated.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
2 066 mg/kg bw
95% CL:
1 693 - 2 530
Mortality:
Animals that died did so within 3 days post exposure.
Clinical signs:
other: Lethargy, hypothermia, piloerection, dyspnea, ataxia
Gross pathology:
No data
Other findings:
No data

Any other information on results incl. tables

4 Animals per sex per dose group

Daily Mortality
Dose ml/kg 1 2 3
M F M F M F
1
1.5
2 3 1 1
3 2 1 1 1
4 1 4 3

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category V
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 is approximately 2.27 ml/kg (2066 mg/kg).
Executive summary:

In this study, male and female rats were gavage with neodecanoic acid at concentrations of 1, 1.5, 2, 3, or 4 ml/kg. All animals that died during the study did so within 3 days of exposure. Signs of toxicity included lethargy, hypothermia, piloerection, dyspnea, and ataxia. Based on these results, it is concluded that the LD50 is approximately 2.27 ml/kg (2066 mg/kg).