Registration Dossier

Administrative data

Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
6 December 1994 and 14 April 1995
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1995
Report date:
1995

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.2 (Boiling Temperature)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
The work described was performed in compliance with the UK Principles of Good Laboratory Practice (The United Kingdom Compliance Programme, Department of Health 1989).
Type of method:
distillation method

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Boiling point
Boiling pt.:
418 - 591 K
Atm. press.:
101.81 - 103.37 kPa

Any other information on results incl. tables

Results

Determination 1

Vapour temperature (K) Sample temperature (K) Observations
290 291 The test material was a clear, colourless liquid
290 336 There was no change in the test material
293 376 There was no change in the test material
300 416 There was no change in the test material
304 435 There was no change in the test material
308 474 Convection currents were visible in the test material
315 510 There was no change in the test material
333 539 There was no change in the test material
344 556 The convection currents were more vigorous
348 571 Bubbles were being formed in the test material
354 593 The test material was bubbling gently
360 602 The test material was bubbling steadily
375 613 Ther test material was bubbling vigorously
388 619 Colourless liquid was forming at the top of the condenser
418 626 The first drop of clear, colourless distillate was collected
477 630 1 ml of clear colourless distillate had been collected
531 634 5 ml of clear colourless distillate had been collected. White vapour had formed in the apparatus
549 >634 10 ml of clear colourless distillate had been collected
567 >634 20 ml of clear colourless distillate had been collected
575 >634 30 ml of clear colourless distillate had been collected
580 >634 40 ml of clear colourless distillate had been collected
583 >634 50 ml of clear colourless distillate had been collected
585 >634 60 ml of clear colourless distillate had been collected
588 >634 70 ml of clear colourless distillate had been collected
590 >634 80 ml of clear colourless distillate had been collected
591 >634 90 ml of clear colourless distillate had been collected
585 >634 95 ml of clear colourless distillate had been collected
553 >634 97.5 ml of clear colourless distillate had been collected
520 >634 Distillation had ceased. 98.5 ml of clear colourless distillate had been collected. On concluding the test, 1 ml of clear very pale liquid remained in the sample flask.

Boiled over the range 418 to 591 +/- 0.5 K, leaving a residue

Determination 2

Vapour temperature (K) Sample temperature (K) Observations
295 294 The test material was a clear, colourless liquid
295 331 There was no change in the test material
299 381 There was no change in the test material
303 413 There was no change in the test material
311 439 There was no change in the test material
316 461 Convection currents were visible in the test material
323 500 There was no change in the test material
335 542 There was no change in the test material
346 555 The convection currents were more vigorous
349 570 Bubbles were being formed in the test material
363 599 The test material was bubbling gently
370 609 Ther test material was bubbling vigorously
377 614 Condensate had entered the condenser
453 621 The first drop of clear, colourless distillate was collected
485 624 1 ml of clear colourless distillate had been collected
523 626 5 ml of clear colourless distillate had been collected. White vapour had formed in the apparatus
541 632 10 ml of clear colourless distillate had been collected
559 634 20 ml of clear colourless distillate had been collected
569 >634 30 ml of clear colourless distillate had been collected
575 >634 40 ml of clear colourless distillate had been collected
580 >634 50 ml of clear colourless distillate had been collected
583 >634 60 ml of clear colourless distillate had been collected
586 >634 70 ml of clear colourless distillate had been collected
589 >634 80 ml of clear colourless distillate had been collected
590 >634 90 ml of clear colourless distillate had been collected
580 >634 95 ml of clear colourless distillate had been collected
553 >634 97 ml of clear colourless distillate had been collected
511 >634 Distillation had ceased. 98 ml of clear colourless distillate had been collected. 
    On concluding the test, 1 ml of clear very pale liquid remained in the sample flask.

Boiled over the range 453 to 590 +/- 0.5 K, leaving a residue

Applicant's summary and conclusion

Conclusions:
Alkane 2 was found to boil over the range approximately 418 - 591 +/- 0.5 K at 102 kPa.
Executive summary:

The experimental procedure used complied with that specified in Method A2 of Commission Directive 92/69/EEC (which constitutes Annex V of Council Directive 67/548/EEC).

Alkane 2 was found to boil over the range approximately 418 - 591 +/- 0.5 K at 102 kPa.