trans-1,4-bis(isocyanatomethyl)cyclohexane

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics

Type of information:

other: expert statement

Adequacy of study:

key study

Study period:

2018

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Theoretical assessment taking all currently available relevant information into account, based on the REACH Guidance: Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.7c Endpoint specific guidance. Since this is a theoretical assessment, the Klimisch value cannot be 1.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

GLP compliance:

no

Test material

Reference

Name:

Unnamed

Type:

Constituent

Test material form:

liquid

Results and discussion

Main ADME results

Type:

absorption

Results:

For risk assessment purposes, 100% is used for oral, dermal and inhalation absorption

Applicant's summary and conclusion

Conclusions:

A toxicokinetic assessment was performed based on the available data of 1,4-H6XDI. Based on the physical/chemical properties of 1,4-H6XDI, absorption factors are derived to be 100% (oral, inhalation and dermal) for risk assessment purposes. The bioaccumulation potential is expected to be low.