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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1985
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1986
Report date:
1986

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method B.3 (Acute Toxicity (Dermal))
Version / remarks:
The studies were performed in accordance with EC Directives 84/449 (Official Journal of the European Communities 27, 1984, L 251, 103).
Deviations:
no
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3-(dimethylamino)propylurea
EC Number:
401-950-2
EC Name:
3-(dimethylamino)propylurea
Cas Number:
31506-43-1
Molecular formula:
C6H15N3O
IUPAC Name:
3-dimethylaminopropyl urea
Test material form:
liquid
Remarks:
extremely pale straw coloured viscous liquid
Specific details on test material used for the study:
Name: N-(3-(dimethylamino)-propy1)urea = HST 2844
Batch no.: Batch 12
Aggregate state: Liquid
External properties: Brownish clear liquid
Storage: At room temperature

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
other: Lutrol (manufacturer: Merck-Schuchard, Art. No.: 807485)
No. of animals per sex per dose:
5 male and 5 female animals

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 2 050 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
TThe dermal LD50 of 3-(dimethylamino)propylurea in rats is greater than 2050 mg/kg of bodv weight