1,3-bis[3-(dimethylamino)propyl]urea

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1985

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1986

Report date:

1986

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

EU Method B.3 (Acute Toxicity (Dermal))

Version / remarks:

The studies were performed in accordance with EC Directives 84/449 (Official Journal of the European Communities 27, 1984, L 251, 103).

Deviations:

no

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

3-(dimethylamino)propylurea

EC Number:

401-950-2

EC Name:

3-(dimethylamino)propylurea

Cas Number:

31506-43-1

Molecular formula:

C6H15N3O

IUPAC Name:

3-dimethylaminopropyl urea

Test material form:

liquid

Remarks:

extremely pale straw coloured viscous liquid

Specific details on test material used for the study:

Name: N-(3-(dimethylamino)-propy1)urea = HST 2844
Batch no.: Batch 12
Aggregate state: Liquid
External properties: Brownish clear liquid
Storage: At room temperature

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Type of coverage:

occlusive

Vehicle:

other: Lutrol (manufacturer: Merck-Schuchard, Art. No.: 807485)

No. of animals per sex per dose:

5 male and 5 female animals

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 2 050 mg/kg bw

Based on:

test mat.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

TThe dermal LD50 of 3-(dimethylamino)propylurea in rats is greater than 2050 mg/kg of bodv weight