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Ecotoxicological information

Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Test organisms (species):
Oryzias latipes
Details on test organisms:
This species is similar in sensitivity to carp and readily available as test fish.
Test type:
semi-static
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
> 1 000 mg/L
Validity criteria fulfilled:
yes
Conclusions:
The test item was a mixture of the reaction products (1-(3-(Dimethylamino)propyl)urea (CAS 31506-43-1, EC 401-950-2, monoDMAPAU) )and 1,3-bis[3-(dimethylamino)propyl]urea (CAS 52338-87-1, EC 257-861-2, bisDMAPAU)
The 96-hour LC50 for orange red killifish (Oryzias latipes))exposed to DMPA Urea was >1000 mg/l

Description of key information

The test item was a mixture of the reaction products (1-(3-(Dimethylamino)propyl)urea (CAS 31506-43-1, EC 401-950-2, monoDMAPAU) )and 1,3-bis[3-(dimethylamino)propyl]urea (CAS  52338-87-1, EC 257-861-2, bisDMAPAU).

The 96-hour LC50 for orange red killifish (Oryzias latipes))exposed to DMPA Urea was >1000 mg/l

Key value for chemical safety assessment

LC50 for freshwater fish:
1 000 mg/L

Additional information

The 96-hour LC50 for orange red killifish (Oryzias latipes) exposed to DMAPA Urea was > 1000 mg/l