Registration Dossier
Registration Dossier
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EC number: 232-796-2 | CAS number: 9025-49-4
Endpoint summary
Administrative data
Description of key information
Aspergillopepsin I has not been tested. Read-across to subtilisin and sedolisin is applied for the acute toxicity towards fish, daphnia and the algal growth inhibition study, respectively.
Both subtilisin and sedolisin belong to the same enzyme subclass 3.4 as aspergillopepsin I and read-across is considered fully applicable (see also read-across conclusions). All studies were conducted according to OECD guidelines. Fish was found to be the most sensitive species for acute effects.
The results from the aquatic studies are following:
Daphnia immobilisation test (read-across from sedolisin): ErC50 (72 h) > 100 mg TOS/L (> 24.7 mg aep/L), NOEC (72 h) 10 mg TOS/L (2.5 mg aep/L).
Algal growth inhibition (read across from sedolisin): ErC50 (72h) > 24.7 mg aep/L, NOEC (72h) 2.5 mg aep/L
Fish acute toxicity (read-across from subtilisin): LC50 (96h) 8.2 mg aep/L, NOEC (96h) 5.7 mg aep/L
The LC50 value from the fish acute toxicity study is used for PNEC derivation
Additional information
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