Registration Dossier

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Genetic toxicity in vitro

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (positive)

Genetic toxicity in vivo

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Additional information

Short description of key information:
The genotoxicity of Basic Red 76 is sufficiently investigated for the endpoints of gene mutations, chromosome aberrations and aneuploidy. Basic Red 76 did not induce gene mutations in bacteria and in mammalian cells. In an in vitro micronucleus test Basic Red 76 treatment did result in an increase in V79 cells with micronuclei. The positive finding in the in vitro micronucleus test was not confirmed in an adequately performed in vivo bone marrow test. Basic Red 76 can be considered to have no in vivo genotoxic potential.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

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