Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 222-212-4 | CAS number: 3387-41-5
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 442D (In Vitro Skin Sensitisation: ARE-Nrf2 Luciferase Test Method)
- GLP compliance:
- yes
- Type of study:
- other: LuSens Test
Test material
- Reference substance name:
- Thuj-4(10)-ene
- EC Number:
- 222-212-4
- EC Name:
- Thuj-4(10)-ene
- Cas Number:
- 3387-41-5
- Molecular formula:
- C10H16
- IUPAC Name:
- 4-methylidene-1-(propan-2-yl)bicyclo[3.1.0]hexane
Constituent 1
Results and discussion
In vitro / in chemico
Results
- Key result
- Parameter:
- other: relative viability
- Value:
- 70
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Under the experimental conditions of this study, the test item, Thuj-4(10)-ene, was nega-tive in the LuSens assay and is therefore considered not having the potential to activate the Nrf2 transcription factor. However, due to the low test item concentrations (highest concentrations < 1000 µM), the result has to be considered as inconclusive in accordance to the OECD 442D.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
