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Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017
Reliability:
1 (reliable without restriction)
Qualifier:
according to
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
GLP compliance:
yes
Test type:
fixed dose procedure
Species:
rat
Sex:
female
Route of administration:
oral: drinking water
Vehicle:
olive oil
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
>= 300 - <= 2 000 mg/kg bw
Based on:
other: Wistar rats
Mortality:
Test item-related mortality in females treated with the test item in dose of 2000 mg/kg body weight was observed within the 48 hours.
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
Based on Annex 2d Test Procedure with a Starting Dose of 2000 mg/kg body weight of OECD Guideline 423 it can be concluded that the test item Thuj-4(10)-ene is classified in Category 4 with a LD50 cut off value 2000 mg/kg body weight, after single oral administration to Wistar rats.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Additional information

Justification for classification or non-classification