Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 235-719-0 | CAS number: 12609-95-9
The short-term toxicity to aquatic algae of 1,1'-Bis(ferrocenyl)octane, CAS Number 501410-94-2, EC Number 479-710-1was investigated in accordance with the standardised guideline OECD 201.
An OECD 201 study conducted to GLP in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results was performed on 1,1'-Bis(ferrocenyl)octane, CAS Number 501410-94-2, EC Number 479-710-1.
The study was assigned a reliability score of 1 in accordance with the criteria for assessing data quality set forth by Klimisch et al. (1997).
This substance is considered to be sufficiently close in structural integrity to 1,1''-isopropylidenediferrocene, CAS Number 12609-95-9, EC Number 235-719-0 so as to justify valid read across.
Under the conditions of the study 1,1'-Bis(ferrocenyl)octan, has an 72hour EC50 of > 0.36mg/L (measured) to Algae. The NOEC was 0.36mg/L. The nominal value added to the water of 0.5mg/L is 10x the water solubility of the molecule.
The short-term toxicity to aquatic algae of iron(2+) dicyclopenta-2,4-dienide (ferrocene), CAS Number 102-54-5, EC Number 203-039-3 was investigated in a study which was equivalent or similar to guideline OECD 201.
The study was assigned a reliability score of 2 in accordance with the criteria for assessing data quality set forth by Klimisch et al. (1997).
In this study, ferrocene produced an EC50 (72hr) = 1.03 mg/l and an EC10 (72hr) = 0.14 mg/l. The values of the algal growth inhibition are in accordance with the data in and of the same magnitude as the values for daphnia acute toxicity. The samples were diluted in acetone to enable solubilisation.
Two studies are presented on structurally related substances as valid read across candidates: 1,1'-Bis(ferrocenyl)octane, CAS Number 501410-94-2, EC Number 479-710-1 (OECD 202) and Iron(2+) dicyclopenta-2,4-dienide (Ferrocene), CAS Number 102-54-5, EC Number 203-039-3 (equivalent or similar to OECD 202).
In an OECD 201, 1,1'-Bis(ferrocenyl)octan, has an 72hour EC50 of > 0.36mg/L (measured) to Algae. The NOEC was 0.36mg/L. The nominal value added to the water of 0.5mg/L is 10x the water solubility of the molecule.
In the case of iron (2 +) dicyclopenta-2,4 -dienide (ferrocene), CAS Number 102 -54 -5, EC Number 203 -039 -3, a study performed that was equivalent or similar to OECD Guideline 201 an EC50 (72hr) = 1.03 mg/l and an EC10 (72hr) = 0.14 mg/l were observed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again