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EC number: 815-461-0
CAS number: -
INDIVIDUAL SKIN IRRITATION SCORES
Following exposure, the treated
skin-area remained fatty after removal of the test substance.
Time after exposure
Comments: R. Erythema at the edges of
the application-area; b. Sticky remnants of the test substance present
at the edges of the application-area.
MEAN VALUE IRRITATION SCORES
Mean 24-72 hrs
Age at start (weeks)
Prior to application
Primary skin irritation/corrosion study with HATCOL
3331 in the rabbit (4-hour semi-occlusive application).
The study was carried out based on the guidelines
described in: EC Commission Directive 92/69/EEC, B4, "Acute Toxicity -
Skin irritation", OECD No 404, "Acute Dermal Irritation/Corrosion",
US EPA, OPPTS 870.2500, Acute Dermal Irritation and JMAFF,
Three rabbits were exposed to 0.5 ml of HATCOL 3331,
applied onto clipped skin for 4 hours using a semi-occlusive dressing.
Observations were made 1, 24, 48 and 72 hours after exposure.
Exposure to HATCOL 3331 resulted in very slight
erythema and/or very slight oedema in the treated skin-areas of the
rabbits, which had resolved within 24 hours in two animals and within48
hours in the other animal.
Sticky remnants of the test substance were present on
the edges of the treated skin area on day 1.
Based on the results and according to the EC criteria
for classification and labelling requirements for dangerous substances
and preparations (Council Directive 67/548/EEC), HATCOL 3331 does not
have to be classified and has no obligatory labelling requirement for
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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