Registration Dossier
Registration Dossier
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EC number: 701-265-1 | CAS number: -
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
The available data suggest no acute or chronic, oral or dermal effects of the ferrous slags. From mutagenicity studies and despite the widespread use of the ferrous slags, no CMR potential or other health effect of these slags is identified.
The only critical exposure pathway to humans is the inhalation of the dust of fine-grained ferrous slag. Therefore exposure by inhalation is considered to be relevant as a threshold mode of action especially for workers. GGBS is considered to cover the worst-case of ferrous slag, because it is intentionally ground for the cement industry and thus contains by far the highest amount of fine and inhalable particles compared to other types of ferrous slag.
Inhalation tests have demonstrated the absence of acute toxicity on vertebrates.
For GGBS a subacute inhalation study (according OECD Guideline 412) was done. Based on the results of this study, the No Adverse Effect Level (NOAEL) was determined to be 24 mg/m³ (target concentration) or 24.9 mg/m³ (achieved concentration).
However, the dust limit values - eight hours for inhalable dust are 10 mg/m³ in the European countries which have one and for respirable dust between 3 and 6 mg/m³. Those general dust limits covers all potential effects of inert dusts. The dust limit values of 10 mg/m³ (inhalable dust) and 3 mg/m³ (respirable dust) will therefore be used as DNEL’s for chronic exposure for the whole group.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Exposure of the general population to slags is only incidental.
There are several methods applied to decrease the potential exposure of the general population to ferrous slags e.g.
covering e.g. in road construction by the surface layer of the road
inclusion in matrix e.g. use of slags in asphalt or concrete
reduction of dusting behaviour by e.g. wetting or pelettization
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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