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EC number: 402-150-6
CAS number: 118578-11-3
C.I. REACTIVE RED 231
A Test Sample of Substance H111567 has been evaluated in the
Salmonella mutagenicity assay of Maron and Ames (1983).
In two separate experiments, the Test Sample did not induce any
significant reproducible increases in the observed numbers of revertant
colonies in any of the tester strains used (TA1535, TA1537, TA1538, TA98
and TA100) in the absence of any auxiliary metabolising system (S9), nor
in strains TA1535, TA1537, TA98 and TA100 in the presence of S9.
In experiment 1, the compound induced an increase in observed
revertant colony numbers in strain TA1538 (+S9), reaching a maximum
response of 2.1x the background mutation rate at 200 µg/plate. This
response was without dose-relationship, but was highly statistically
significant (p<0.005 at 1000 and 200 µg/plate). In the second
experiment, again an increase in mutation frequency that was not
dose-related was observed in strain TA1538 (+S9) reaching 2.05x the
background mutation rate at 1000 µg/plate. In a third experiment over
the narrower dose range of 5000-100 µg/plate, a slight increase in
revertant colony numbers was again observed in strain TA1538 (+S9),
reaching a maximum of 1.75x the background mutation rate at
1000 µg/plate without however reaching the 2-fold level. However,
although a very slight effect was observed in all three assays in strain
TA1538 (+S9), both criteria for a positive result were not obtained in
these experiments. The test substance was hence considered not to be
mutagenic in the Salmonella mutagenicity assay.
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