Registration Dossier

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
not specified
Type of method:
flask method

Test material

Constituent 1
Chemical structure
Reference substance name:
Reaction mass of N-(3-{[(2E)-3-(4-methoxyphenyl)prop-2-enoyl]amino}propyl)-N,N-dimethyldocosan-1-aminium chloride and N-(3-{[(2E)-3-(4-methoxyphenyl)prop-2-enoyl]amino}propyl)-N,N-dimethylicosan-1-aminium chloride
EC Number:
947-079-6
IUPAC Name:
Reaction mass of N-(3-{[(2E)-3-(4-methoxyphenyl)prop-2-enoyl]amino}propyl)-N,N-dimethyldocosan-1-aminium chloride and N-(3-{[(2E)-3-(4-methoxyphenyl)prop-2-enoyl]amino}propyl)-N,N-dimethylicosan-1-aminium chloride
Test material form:
other: paste
Specific details on test material used for the study:
Product identification: GalHueShield HCS
Batch: GHS-HCS#08
Appearance: Off white pasty solid
Solids, % by mass: 30.38

Results and discussion

Water solubilityopen allclose all
Water solubility:
0 other: kg/kg as mass of solute per mass of solution
Conc. based on:
test mat.
Temp.:
25 °C
pH:
ca. 5.3
Water solubility:
182 mg/L
Conc. based on:
test mat.
Temp.:
25 °C
pH:
ca. 5.3

Any other information on results incl. tables

Experimental data:

No

Period (equilibration time)

Temperature

pH of aqueous solution

Solubility

 

(h)

(°C)

 

(kg/m3)

1

24

25

5.30

0.137

2

24

25

5.35

0.127

3

48

25

5.30

1.175

4

48

25

5.32

0.200

5

72

25

5.31

0.170

6

72

25

5.35

0.183

Average

0.182 kg/m3

Experiment No. 3 to 6 are considered for calculated the average value as the variation is within ±15%.

Density of water at 25 °C is 997.045 kg/m3

So the solubility is:

Solubility (in kg/kg) = 0.182 kg/m3 / 997.045 kg/m3 = 1.82 x 10-4 kg/kg

Applicant's summary and conclusion

Conclusions:
The solubility of GalHueShield HCS in water is 1.82 x 10-4 kg/kg at 25°C expressed as mass of solute per mass of solution (equivalent to 182 mg/L).
Executive summary:

The water solubility of GalHueShield HCS was determined as per OECD Guideline No. 105 (flask method).

The solubility of GalHueShield HCS in water is 1.82 x 10-4 kg/kg at 25°C expressed as mass of solute per mass of solution (equivalent to 182 mg/L).