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EC number: 309-811-7
CAS number: 101033-44-7
study was conducted on triethanolamine, the strucural analogue and also
the hydrolysis product of the
target substance. As the target substance is hydrolytically unstable,
its intrinsic property lies in the the
hydrolysis products. The result is used as weight of evidence approach
in hazard assessment.
No studies were
conducted on the target substance, Tetrakis
[[2,2',2"-nitrilotris[ethanolato]](1-)-N,O]zirconium. As the target
substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic
properties are related to hydrolysis products of the target substance,
There was no
evidence of any skin sensitizing activity of undiluted TEA for guinea
TEA from four
different suppliers was evaluated in guinea pig skin sensitization
tests. The tests were conducted with 10 control and 20 treated guinea
pigs. The induction patches were applied once a week for up to six hours
for three weeks. Two weeks later challenge patches were applied to both
control and treated guinea pigs. One test was conducted with undiluted
TEA at induction and 90% TEA at challenge and all the other tests were
conducted with 50% TEA at induction and 90% TEA at challenge. None of
the animals showed clinical symptoms during or after the treatment
period and no guinea pigs showed signs of primary irritation of the
skin. Challenge reactions were measured with a reflectometer and average
readings between control and experimental animals were compared. TEA was
not a guinea pig skin sensitizer in these studies. (Adapted from
Cosmetic Ingredient Review 1983)
Based on these
findings, the target substance was considered not skin sensitizing.
The target substance is not classified as skin sensitizer according to
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