Registration Dossier
Registration Dossier
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EC number: 204-889-8 | CAS number: 128-49-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: An LC50 study was mentioned in the IUCLID 2000 dossier, however only very few details are available.
- Justification for type of information:
- No data are available for the registered substance, however Klimisch 4 data concerning acute inhalation toxicity are available for the corresponding sodium salt of the substance, docusate sodium (CAS 577-11-7).
Data source
Reference
- Reference Type:
- secondary source
- Title:
- LC50 of Substance 577-11-7
- Author:
- ECB
- Year:
- 2 000
- Bibliographic source:
- IUCLID Datasets
Materials and methods
- Test type:
- standard acute method
Test material
- Reference substance name:
- Docusate sodium
- EC Number:
- 209-406-4
- EC Name:
- Docusate sodium
- Cas Number:
- 577-11-7
- Molecular formula:
- C20H38O7S.Na
- IUPAC Name:
- sodium 1,4-bis[(2-ethylhexyl)oxy]-1,4-dioxobutane-2-sulfonate
- Details on test material:
- AEROSOL OT 100%
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- other: no experimental data provided
- Duration of exposure:
- 96 h
Results and discussion
Effect levels
- Dose descriptor:
- LC50
- Effect level:
- 20 mg/L air
- Based on:
- act. ingr.
- Exp. duration:
- 96 h
Applicant's summary and conclusion
- Conclusions:
- LC50 = 20 mg/L
- Executive summary:
No data are available for the registered substance, however Klimisch 4 data concerning acute inhalation toxicity are available for the corresponding sodium salt of the substance, docusate sodium (CAS 577-11-7).
Exposure of rats to docusate sodium for 96 hours led to an LC50 of 20 mg/L.
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