Registration Dossier

Administrative data

Endpoint:
boiling point
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is a solid which decomposes before boiling
Cross-reference
Reason / purpose:
data waiving: supporting information
Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
23 May 2016 - 02 May 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reference:
Composition 0
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Version / remarks:
2008
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
Version / remarks:
1998
Deviations:
no
GLP compliance:
yes
Type of method:
differential scanning calorimetry
Test material information:
Composition 1
Key result
Melting / freezing pt.:
182.8 °C
Decomposition:
yes
Decomp. temp.:
300 °C

TGA EXPERIMENT (PRELIMINARY TEST)

Significant decrease of weight from 300°C. 25% weight loss at 362°C and 70% weight loss at 445°C.

After the experiment, an orange molten residue remained in the sample container (original colour: off-white). The change of the colour indicated reaction and/or decomposition of the test item.

 

DSC EXPERIMENT 1

An endothermic peak between 150°C and 200°C was observed. The extrapolated onset temperature of the peak was

183.226°C. The effect was most likely obtained due to melting of the test item. An endothermic peak followed by an exothermic peak between 300°C and 362°C was observed. The effect was due to reaction and/or decomposition of the test item. After the experiment, an orange molten residue remained in the sample container. 

DSC EXPERIMENT 2

Experiment 2 was performed to determine the duplicate melting temperature of the test item.

The extrapolated onset of the melting peak was 182.308°C. After the experiment, an off-white molten residue remained in the sample container. Based on visual observations, it can be concluded that the endothermic peak was due to melting of the test item.

DATA HANDLING

The melting temperature was determined as the mean extrapolated onset temperature of Experiment 1 and Experiment 2.

 

Conclusions:
The melting temperature of the substance was determined to be 182.8°C.

Executive summary:

Differential Scanning Calorimetry (DSC) experiments were performed in a GLP study according to EC A.1, OECD 102 and OPPTS 830.7200.

The melting temperature of the substance was determined in duplicate obtaining a mean value of 182.8°C. During heating from 25°C reaction and/or decomposition of the substance started at 300°C.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report Date:
2018

Materials and methods

Results and discussion

Applicant's summary and conclusion