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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
review article or handbook
Title:
Scientific Opinion on the safety and efficacy of Biogalactosidase BL (alphagalactosidase and beta-glucanase) as feed additive for chickens for fattening
Author:
EFSA
Year:
2011
Bibliographic source:
EFSA Journal 2011;9(12):2451

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
not specified
Remarks:
Not reported in this summary report

Test material

Constituent 1
Reference substance name:
Glucanase, β-
EC Number:
232-979-7
EC Name:
Glucanase, β-
Cas Number:
9074-98-0
Molecular formula:
not available (see remarks)
IUPAC Name:
endo-1,4-ß-glucanase IUBMB EC 3.2.1.4
Specific details on test material used for the study:
- Name as used in the study report: glucanase preparation
- concentration: 63000 U/g

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
not specified
Duration of treatment / exposure:
3 min, 1 hour, and 4 hours
Observation period:
72 hours
Number of animals:
3

Results and discussion

In vivo

Results
Remarks on result:
other: see below 'Irritant/corrosive response data'
Irritant / corrosive response data:
Erythaema was seen in two out of three rabbits after 24 and 48 hours which had disappeared after 72 hours.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met