Registration Dossier
Registration Dossier
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EC number: 946-732-2 | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 492 (Reconstructed Human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Liquidambar Styraciflua, oil
- EC Number:
- 946-732-2
- IUPAC Name:
- Liquidambar Styraciflua, oil
Constituent 1
Test animals / tissue source
- Species:
- other: Reconstructed human Cornea-like Epithelium
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent positive control
- yes, concurrent negative control
- Amount / concentration applied:
- 50 μl to 0.6 cm2 RhCE
- Duration of treatment / exposure:
- 30 min
- Duration of post- treatment incubation (in vitro):
- 12 min + 120 min
- Number of animals or in vitro replicates:
- 2
Results and discussion
In vitro
Results
- Irritation parameter:
- other: Viability(%)
- Value:
- 105.92
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Conclusions:
- Under the test conditions applied, the substance is considered as no category.
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