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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Additional toxicological data

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Administrative data

additional toxicological information
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: This information was obtained from the public IUCLID 2000 CD-ROM. The original report has not been reviewed further. Assessment of data quality to current OECD standards is not possible and the study has therefore been assigned Reliability 4.

Data source

Reference Type:
The effects of ethylene-1-hydroxy-1,1-diphosphonate on cellular transformation and organic matrix of the epiphyseal growth plate of the rat: a light microscopic and ultrastructural study
Larsson A and Larsson SE
Bibliographic source:
Acta Pathologica et Microbiologica Scandinavia, SectA Pathology, 86, 211-224

Materials and methods

Type of study / information:
Type: other: effects on bone

Test material

Constituent 1
Reference substance name:
(1-hydroxyethylidene)bisphosphonic acid, sodium salt
EC Number:
EC Name:
(1-hydroxyethylidene)bisphosphonic acid, sodium salt
Molecular formula:
(1-hydroxyethylidene)bisphosphonic acid, sodium salt
Test material form:
not specified
Details on test material:
Substance name as cited in the report: HEDP-xNa

Results and discussion

Applicant's summary and conclusion

EHDP, at the doses used tested had a profound inhibitory effect on the differentiation and migration of the epiphyseal chondrocytes as well as on the degradation of proteoglycan macromolecules. The observed inhibition of vascular invasion appears to be related to inhibition of enzymatic degradation of the ground substance, as evidenced by the observation of extracellular lysosomelike bodies in the erosion zones.