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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
comparable method to OECD guideline, but with some information not present.
Principles of method if other than guideline:
Monsanto Environmental Sciences method ES-79-M-15: Log Kow of the substance was measured by equilibrating aqueous solutions of radiolabelled compounds with n-octanol. The concentrations of the substance in each phase were determined by Liquid Scintillation Counting (LSC).

equilibrating aqueous solutions of radiolabelled compounds with n-octanol
GLP compliance:
no
Type of method:
other: equilibrating aqueous solutions of radiolabelled compounds with n-octanol
Partition coefficient type:
octanol-water
Key result
Type:
log Pow
Partition coefficient:
-3.5
Remarks on result:
other: No other information is given.

Concentration in water (ppm)

Measured octanol/water partition coefficient

100

2.79 x10-4

1000

3.29 x10-4

1000

3.14 x10-4

1000

3.39 x10 -4

average partition coefficient value = 3.15E-4 ( low Pow = -3.50)

Conclusions:
A log Pow value of lower than -3.50 is was obtained by valid read-across. The result is considered to be reliable.

Description of key information

Partition coefficient: log Kow < -3.5 (read across from acid substance)

Key value for chemical safety assessment

Log Kow (Log Pow):
-3.5

Additional information

A log Kow value of -3.5 was determined in a reliable study conducted according to an appropriate test method. The result is considered to be reliable and has been assigned as key study. This value is read across to the sodium salts as log Kow <-3.5 from HEDP parent acid.