Registration Dossier
Registration Dossier
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EC number: 256-589-1 | CAS number: 50448-95-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Methyl 3-mercaptopropionate
- EC Number:
- 220-912-4
- EC Name:
- Methyl 3-mercaptopropionate
- Cas Number:
- 2935-90-2
- Molecular formula:
- C4H8O2S
- IUPAC Name:
- methyl 3-sulfanylpropanoate
- Details on test material:
- IUCLID4 Test substance: as prescribed by 1.1 - 1.4
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Doses:
- 50, 100, 150, 250, 500 and 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 193.6 mg/kg bw
- Mortality:
- All female and male animals died within 4 hours of treatment with 250, 500,
5000 mg/kg bw with the exception of one male animal that
completely recovered by Day 5. - Clinical signs:
- other: Gross signs and symptoms of toxicity exhibited by all rats dosed at 50 and 100 mg/kg bw included only slight depression on Day 1. Clinical signs observed in male and female animals after treatment with 150 mg/kg bw included rough coat, depression, sli
- Gross pathology:
- There were no gross pathological findings noted in rats
surviving to termination. Findings among the rats that were
found dead included dark red lungs, compound-like material
in the stomach and/or intestines, and reddish fluid in the
intestines.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Oral LD50 is 193.6 mg/kg bw.
- Executive summary:
In a study similar to OECD TG 401, male and female Sprague-Dawley rats (5/sex/dose) were administered a single dose of MMP by gavage at dose levels of 50, 100, 150, 250, 500 and 5000 mg/kg bw. The animals were observed for 14 days.
All female and male animals died within 4 hours of treatment with 250, 500,
5000 mg/kg bw with the exception of one male animal that completely recovered by Day 5.LD50 Male: 206.4 mg/kg bw (149.0 to 285.9)
LD 50 Female: 181.7 mg/kg bw (132.6 to 248.9)
LD50 Combined: 193.6 mg/kg bw (154.2 to 243.2)
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