Registration Dossier
Registration Dossier
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EC number: 610-672-2 | CAS number: 51503-61-8
Endpoint summary
Administrative data
Description of key information
LD50 Acute Oral rat > 2000 mg/Kg bw
LD50 Acute Dermal rat > 5000 mg/Kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- The study is a Klimish 1 study
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- The study is a Klimish 1 study
Additional information
Acute toxicity studies per oral and dermal exposure have been performed on the multiconstituent substance "Reaction mass of dipotassium phosphonate and Phosphonic acid, potassium salt (1:1)" (Salvador, 2013) and the results of those studies are also applicable to the Ammonium phosphonate", based on the fact that in the gastric environment the active species is phosphonic acid in both cases. This is true also in the case of dermal exposure, being the skin at slight acidic pH, where the prevalent form is again the cidic form.
No effect has been reported respectively at 2000 and 5000 mg/Kg bw for oral and dermal exposure
Justification for classification or non-classification
Oral acute toxicity
The substance is not classified for oral toxicity because it doesn't meet the classification criteria of the CLP regulation n. 1272/2008:
Oral (mg/kg bodyweight)
Category 1: ATE ≤ 5
Category 2: 5 < ATE≤ 50
Category 3: 50 < ATE≤ 300
Category 4: 300 < ATE≤ 2 000
The substance had no effect at 2000 mg/Kg bw
Inhalation acute toxicity
According to the Annex VIII of the REACH Regulation n. 1907/2006, inhalation route is not considered appropriate, based also on vapour pressure and the test can be waived.
Dermal acute toxicity
The substance is not classified for dermal toxicity because it doesn't meet the classification criteria of the CLP regulation n. 1272/2008:
Dermal (mg/kg bodyweight)
Category 1: ATE ≤ 50
Category 2: 50 < ATE≤ 2000
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