Registration Dossier

Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
September 08, 2005 - September 13, 2005
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2005
Report date:
2005

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
July 27, 1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Version / remarks:
December 1992
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
differential scanning calorimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
457-080-9
EC Name:
-
Cas Number:
32940-15-1
Molecular formula:
C11H12O2
IUPAC Name:
5-Methoxy-3,4-dihydro-1H-naphthalen-2-one
Test material form:
solid: compact
Details on test material:
- Description: White-yellowish solid

Results and discussion

Melting / freezing point
Key result
Melting / freezing pt.:
>= 30.7 - <= 37.6 °C
Atm. press.:
97.5 kPa

Any other information on results incl. tables

Preliminary test

A first endothermic heat effect was observed between 32.7°C and 44.1 °C (melting). A second endothermic heat effect was detected starting at 303.9°C (boiling). After the experiment, the sample had lost about 94 % of its mass and the color of the sample was shiny black and molten.

Main test

- The onset point of the endothermic peak could not be determined accurately. Therefore a melting range is reported.

- First test: melting range of 30.7°C to 37.5°C

- Second test: melting range of 30.6°C to 37.7°C

- During these two tests, the samples lost 0.3 % and 0.4 % of their mass, respectively

- After the measurement both samples were yellowish and molten

- The mean melting range was calculated from the results of the two tests

Applicant's summary and conclusion

Conclusions:
The melting range of the substance was determined to be 30.7-37.6°C.
Executive summary:

Differential Scanning Calorimetry (DSC) experiments were performed in a GLP study according to EC A.1 and OECD 102. A melting range instead of a well defined melting temperature was determined. The mean (n=2) melting range of the substance was determined to be 30.7-37.6°C.