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EC number: 605-420-3 | CAS number: 165950-84-5
Melting point / freezing point
Administrative data
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 Oct 2017 - 20 Nov 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Version / remarks:
- 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- Version / remarks:
- 1998
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- differential scanning calorimetry
Test material
- Reference substance name:
- (6S)-6-(propylamino)-5,6,7,8-tetrahydronaphthalen-1-ol hydrobromide
- EC Number:
- 605-420-3
- Cas Number:
- 165950-84-5
- Molecular formula:
- C13H20BrNO
- IUPAC Name:
- (6S)-6-(propylamino)-5,6,7,8-tetrahydronaphthalen-1-ol hydrobromide
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Appearance: White powder
- Storage condition of test material: At room temperature
Constituent 1
Results and discussion
Melting / freezing point
- Key result
- Melting / freezing pt.:
- 256.5 °C
Any other information on results incl. tables
TGA EXPERIMENT (PRELIMINARY TEST)
No significant weight loss was observed. At 549°C, the sample weight had decreased by 3%.
After the experiment, a black molten residue remained in the sample container. The change of the colour indicated reaction and/or decomposition of the test item.
DSC EXPERIMENT 1
An endothermic peak was observed between 225°C and 275°C. The extrapolated onset temperature of the peak was 256.414°C. The endothermic effect was most likely caused by melting of the test item. An endothermic peak followed by an exothermic peak was observed between 300°C and 400°C. The effects were ascribed to reaction and/or decomposition of the test item.
After the experiment, a brown/black molten residue remained in the sample container. The change of the colour indicated reaction and/or decomposition of the test item. Based on this visual observation, it was concluded that the test item had molten and the change of the colour demonstrated reaction and/or decomposition of the test item.
DSC EXPERIMENT 2
In order to investigate the melting peak, in Experiment 2 heating was stopped directly after the melting peak. The extrapolated onset temperature was 256.540°C. After the experiment, a white molten residue remained in the sample container.
DATA HANDLING
The melting temperature was determined as the mean extrapolated onset temperature of Experiment 1 and Experiment 2.
Applicant's summary and conclusion
- Conclusions:
- The melting temperature of the substance was determined to be 256.5°C.
Reaction and/or decomposition of the substance started at 300°C. - Executive summary:
Differential Scanning Calorimetry (DSC) experiments were performed in a GLP study according to EC A.1, OECD 102 and OPPTS 830.7200.
The melting temperature of the substance was determined in duplicate obtaining a mean value of 256.5°C.
Reaction and/or decomposition of the substance started at 300°C.
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