Registration Dossier
Registration Dossier
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EC number: 201-182-6 | CAS number: 79-16-3
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
- Principles of method if other than guideline:
- LD50 in male mice after i.p. injection
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- N-methylacetamide
- EC Number:
- 201-182-6
- EC Name:
- N-methylacetamide
- Cas Number:
- 79-16-3
- Molecular formula:
- C3H7NO
- IUPAC Name:
- N-methylacetamide
- Details on test material:
- no further data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- 200, 1600, 3200, 4000, 5000, 6400 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 500 mg/kg bw
- Remarks on result:
- other: for males and females combined
Any other information on results incl. tables
Mice died within 7 days.
Clinical signs: increased respiration rate, staggered gait, mice crouched down, dyspnoe, ruffled coat, prone position.
No clinical effects after 7 days.
Necropsy: suspicion for fatty liver at >=4000 mg/kg bw
Applicant's summary and conclusion
- Conclusions:
- LD50 in male & female mice after i.p. injection was 3500 mg/kg bw.
- Executive summary:
LD50 in male & female mice after i.p. injection was 3500 mg/kg bw.
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