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Diss Factsheets
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EC number: 201-182-6 | CAS number: 79-16-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets scientific standards with acceptable restrictions (one dose; partly limited documentation, e.g. no details about the test substance).
Data source
Reference
- Reference Type:
- publication
- Title:
- An investigation on the relationship between the hepatotoxicity and the metabolism of N-alkylformamides
- Author:
- Kestell P, Threadgill MO, Gescher A, Gledhill AP, Shaw AJ, Farmer PB
- Year:
- 1 987
- Bibliographic source:
- J Pharmcol Exp Therap 240: 265-270
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- Metabolism in mice after i.p. injection
- GLP compliance:
- not specified
Test material
- Reference substance name:
- N-methylacetamide
- EC Number:
- 201-182-6
- EC Name:
- N-methylacetamide
- Cas Number:
- 79-16-3
- Molecular formula:
- C3H7NO
- IUPAC Name:
- N-methylacetamide
- Details on test material:
- Source: Aldrich Chemical Co.
no further details
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- mouse
- Strain:
- other: CBA/CA
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Body weight: 18-25 g
no further details
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- physiological saline
- Details on exposure:
- injection volume: 0.2 ml per animal
- Duration and frequency of treatment / exposure:
- Single application
Doses / concentrations
- Remarks:
- Doses / Concentrations:
400 mg/kg bw
- No. of animals per sex per dose / concentration:
- 6
- Control animals:
- no
- Details on study design:
- - Dose selection rationale: comparison with other amides in this study using the same dose level; no toxic effects of the test substance even at a dose level of 3000 mg/kg bw (41.1 mmol/kg; liver enzymes measured and body weight gain)
- Details on dosing and sampling:
- Urine collected 0-24 h after i.p. injection.
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- 2.0 +- 2.0% (mean +- standard deviation) of the applied dose were excreted unchanged in urine.
54 +- 10% were excreted as N-hydroxymethylacetamide (n=5).
Applicant's summary and conclusion
- Conclusions:
- Idendification of N-hydroxymethylacetamide as the main metabolite in urine of mice treated with N-methylacetamide.
- Executive summary:
Meets scientific standards with acceptable restrictions (one dose; partly limited documentation, e.g. no details about the test substance).
Mice received i.p. 400 mg/kg bw and metabolites in the 24 -h urine were determined. Only 2.0 +-2.0% of the applied dose were excreted unchanged but 54 +-10% as N-hydroxymethylacetamide. The metabolic pathway is clearly different from that of N-methylformamide and these differences are paralleled by differences in hepatotoxicity (no hepatotoxicity of N-methylacetamide even at a dose level of i.p. 3000 mg/kg bw but hepatotoxic effects of N-methylformamide at >=200 mg/kg bw)
Conclusion: Idendification of N-hydroxymethylacetamide as the main metabolite in urine of mice.
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