Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
10th October 2016 to 05th September 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
yes (incl. QA statement)
Type of method:
other: total organic carbon

Test material

Constituent 1
Reference substance name:
Undecanolactone
EC Number:
254-399-3
EC Name:
Undecanolactone
Cas Number:
39282-36-5
Molecular formula:
C11H20O2
IUPAC Name:
undecanolactone

Results and discussion

Water solubility
Key result
Water solubility:
> 22 - 160 mg/L
Conc. based on:
test mat.
Remarks on result:
other: Results not applicable to template. Water solubility values of 22 and 160 mg/L at low and high test loadings were given.
Details on results:
Results of the test and show water solubility values of approximately 22 and 160 mg/L at the low and high test loadings respectively. The increase in solubility with loading, and the apparent increase in solubility with time at the higher test loading, indicated that minor impurities are likely to have contributed significantly to these values. Based on structure, the solubility of the test item itself was anticipated to be much lower.

Any other information on results incl. tables

Computer modelling ((WSKOWWIN, Version 1.42, U.S. Environmental

Protection Agency) indicated a water solubility of much less than 1 mg/L for the substance.

The solubility value of 22 mg/L should be considered to be a maximum value.

Applicant's summary and conclusion

Conclusions:
The substance's water solubility was studied in accordance with EU Method A.6 and OECD Guideline 105 via a GLP-certified laboratory. Using total carbon capture, the water solubility of the substance was determined to be < 22 mg/L. The increase in solubility with loading, and the apparent increase in solubility with time at the higher test loading, indicated that minor impurities are likely to have contributed significantly to the values obtained. Computer modelling indicated a water solubility of much less than 1 mg/L for the substance.
Executive summary:

The substance's water solubility was studied in accordance with EU Method A.6 and OECD Guideline 105 via a GLP-certified laboratory. Using total carbon capture, the water solubility of the substance was determined to be < 22 mg/L. The increase in solubility with loading, and the apparent increase in solubility with time at the higher test loading, indicated that minor impurities are likely to have contributed significantly to the values obtained. Computer modelling indicated a water solubility of much less than 1 mg/L for the substance.