Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Acute oral toxicity studies were conducted with two TDI-I category members, Diurea 8 and Tetraurea 2. The results from these studies showed no evidence of acute toxicity up to the highest dose tested in either study (2000 mg/kg test item in arachis oil BP). There is no evidence of a relevant intrinsic acute oral toxicity requiring classification or substance specific risk management measures.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating dose
2 000 mg/kg bw
Quality of whole database:

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

The oral LD50 value is greater than 2000 mg/kg bw in both studies conducted with TDI-I category members, therefore existing data supports the justification for non-classification.