Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 922-435-3 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Aquatic toxicity endpoints are based on test data following standard guidelines. All data are therefore considered to be reliable and relevant for the endpoint concerned.
Short-term toxicity to aquatic invertebrates
In acute ecotoxicity studies with Daphnia magna, Diurea 8 and Tetraurea 2 (in base grease) had 48-Hour EL50 (effective loading rate) values of greater than 100 mg/L WAF. The No Observed Effect Loading Rate (NOELR) for both Diurea 8 and Tetraurea 2 was 100 mg/L WAF.
The toxicity of Reaction product of m-tolylidene diisocyanate and cyclohexylamine and cyclohex-1,2-ylenediamine and (Z)-octadec-9-enylamine (in isolated form) toDaphnia magnawas investigated in an OECD guideline 202 study and the 48-hour EC50, based on nominal concentrations, was determined to be > 100 mg/L, the only concentration tested. The 48-hour NOEC was determined to be ≥ 100 mg/L.
Based on study results for category members, no toxicity to aquatic invertebrates is expected at the limit of solubility for substances within the TDI-I category.
Toxicity to aquatic algae and cyanobacteria
The effects of two TDI-I category members on the growth of Pseudokirchneriella subcapitata were investigated in two separate studies (one conducted in base grease and one conducted on the isolated thickener). The studies followed OECD guideline 201 and used water accommodated fractions. Both studies demonstrated EL50 (effective loading rate) values of greater than 100 mg/L WAF. Correspondingly the No Observed Effect Loading Rates (NOELR) were 100 mg/L WAF.
One study conducted with Diurea 8 in base grease did show effects at <100 mg/L, but this was considered to be due to impurities in the sample, and therefore the study was repeated on both the isolated substance and the substance in base grease. Both of these studies showed EL50 values >100 mg/L WAF and NOELR values of 100 mg/L WAF. The first study is therefore disregarded due to impurities in the test sample.
Based on the available data for category members, TDI-I substances are not considered to be toxic to algae at the limit of solubility.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
